SMARCAL1 antibody (AA 904-954)
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- Target See all SMARCAL1 Antibodies
- SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1))
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Binding Specificity
- AA 904-954
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SMARCAL1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Purpose
- Rabbit anti-SMARCAL1 Antibody, Affinity Purified
- Predicted Reactivity
- Bovine
- Purification
- Affinity Purified
- Immunogen
- between AA 904 and 954
- Isotype
- IgG
- Top Product
- Discover our top product SMARCAL1 Primary Antibody
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- Application Notes
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Expiry Date
- 12 months
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- Target
- SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1))
- Alternative Name
- SMARCAL1 (SMARCAL1 Products)
- Synonyms
- SMARCAL1 antibody, im:7145331 antibody, si:ch211-239d11.1 antibody, harp antibody, hharp antibody, 6030401P21Rik antibody, AI851716 antibody, Mharp antibody, HARP antibody, HHARP antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 antibody, SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 antibody, Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 L homeolog antibody, SMARCAL1 antibody, smarcal1 antibody, Smarcal1 antibody, smarcal1.L antibody
- Background
- Background: The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCAL1 is a member of the SNF2 family. SMARCAL1 is also known as human hep-related protein (HARP) due to its sequence identity with the E. coli RNA polymerase-binding protein HepA. It has been determined that mutations in SMARCAL1 are the cause of Schimke immuno-osseous dysplasia (SIOD), an autosomal-recessive disorder characterized by spondyloepiphyseal dysplasia, renal dysfunction, facial dysmorphism, and T-cell immunodeficiency. The pleiotropic characteristics of SIOD indicate an important role for SMARCAL1 in the regulation of multiple genes that influence the proliferation of chondrocytes, lymphocytes, and spermatozytes, as well as the development of cardiomyocytes and vascular homeostasis.
- Gene ID
- 50485
- NCBI Accession
- NP_054859
- UniProt
- Q9NZC9
- Pathways
- Embryonic Body Morphogenesis
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