CDKN1C antibody (AA 266-316)

Catalog No. ABIN7452239

The Rabbit Polyclonal anti-CDKN1C antibody has been validated for IP. It is suitable to detect CDKN1C in samples from Human.

Quick Overview for CDKN1C antibody (AA 266-316) (ABIN7452239)

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN1C antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-CDKN1C Antibody

Binding Specificity: AA 266-316

Purpose: Rabbit anti-p57kip2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 266 and 316

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. ABIN7452239 has not performed satisfactorily when used for WB of p57KIP2 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of p57KIP2.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CDKN1C

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Alternative Name: p57kip2

Background: Background: p57kip2 is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate [taken from NCBI GeneID:1028].

Gene ID: 1028

NCBI Accession: NP_000067

UniProt: P49918

Pathways: Cell Division Cycle, Dopaminergic Neurogenesis