PPM1B antibody (AA 400-450)

Catalog No. ABIN7452400

This Rabbit Polyclonal antibody specifically detects PPM1B in IP. It exhibits reactivity toward Human.

Quick Overview for PPM1B antibody (AA 400-450) (ABIN7452400)

Target: PPM1B (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPM1B antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-PPM1B Antibody

Binding Specificity: AA 400-450

Purpose: Rabbit anti-PPM1B Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 400 and 450

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-PPM1B antibody ABIN7450594.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PPM1B

Target: PPM1B (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B))

Alternative Name: PPM1B

Background: Background: Members of the protein phosphatase 2C (PP2C) family of isoenzymes are serine/threonine protein phosphatases that act as monomers, are magnesium or manganese dependent, and are structurally distinct from PP1, PP2A, and PP2B protein phosphatases. There are 14 mammalian PP2C genes that encode for members of the PP2C family of isoenzymes. Members of this family include PP2C alpha (PPM1A), PP2C beta (PPM1B), PP2C gamma (PPM1G), and PP2C delta (PPM1D). PPM1B represents the protein phosphatase 2C (PP2C) beta isoform 1. Six splice variants of the PPM1B have been identified PPM1B activation by lipophilic compounds has been demonstrated to be associated with the induction of apoptosis PPM1B activity has been shown to be involved in cell cycle control and the dephosphorylation of cyclin dependent kinases cdk2 and cdk6.

Gene ID: 5495

NCBI Accession: NP_002697

UniProt: O75688