RAD17 antibody (AA 564-614)

Catalog No. ABIN7452689

The Goat Polyclonal anti-RAD17 antibody has been validated for WB and IP. It is suitable to detect RAD17 in samples from Human.

Quick Overview for RAD17 antibody (AA 564-614) (ABIN7452689)

Target: RAD17

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This RAD17 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-RAD17 Antibody

Binding Specificity: AA 564-614

Purpose: Goat anti-Rad17 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: between AA 564 and 614

Isotype: IgG

Application Details

Application Notes:

IP: 40 μL/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RAD17

Target: RAD17

Alternative Name: Rad17

Background: Background: Rad17 is a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. [taken from the Universal Protein Resource (UniProt) O75943].

Gene ID: 5884

NCBI Accession: NP_579917

UniProt: O75943