CHEK1 antibody (AA 200-250)
Quick Overview for CHEK1 antibody (AA 200-250) (ABIN7453256)
Target
See all CHEK1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 200-250
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Purpose
- Goat anti-Chk1 Antibody, Affinity Purified
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Predicted Reactivity
- Mouse,Rat
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Purification
- Affinity Purified
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Immunogen
- between AA 200 and 250
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Isotype
- IgG
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Application Notes
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IP: Not recommended
WB: 1:2,500 - 1:15,000
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Restrictions
- For Research Use only
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Concentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Expiry Date
- 12 months
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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Alternative Name
- Chk1
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Background
- Background: Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c.
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Gene ID
- 1111
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NCBI Accession
- NP_001265
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UniProt
- O14757
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Pathways
- p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair
Target
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