CEP290 antibody (AA 2429-2479)

Catalog No. ABIN7453386

This anti-CEP290 antibody is a Rabbit Polyclonal antibody detecting CEP290 in WB, IP and IF/ICC. Suitable for Human.

Quick Overview for CEP290 antibody (AA 2429-2479) (ABIN7453386)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC)

Product Details anti-CEP290 Antibody

Binding Specificity: AA 2429-2479

Purpose: Rabbit anti-CEP290 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 2429 and 2479

Isotype: IgG

Application Details

Application Notes:

ICC-IF: 1:250 - 1:1,000. Formaldehyde fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290

Background: Background: Centrosomal protein 290 (CEP290) is a member of the nephrocystins, a family of proteins involved in renal cystic diseases. CEP290 and the nephrocystins appear to play a role in cilia and basal body function. Loss-of-function mutations in CEP290 result in Joubert syndrome and related disorders characterized by brain malformations, developmental delay, ataxia, irregular breathing, renal disease, and hepatic fibrosis.

Gene ID: 80184

NCBI Accession: NP_079390

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase