GTF3C2 antibody (AA 75-125)

Catalog No. ABIN7454394

Product Details anti-GTF3C2 Antibody

Target: GTF3C2 (General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2))

Binding Specificity: AA 75-125

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF3C2 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-GTF3C2/TFIIIC110 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: between AA 75 and 125

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for GTF3C2

Target: GTF3C2 (General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2))

Alternative Name: GTF3C2/TFIIIC110 (GTF3C2 Products)

Synonyms: TFIIIC110 antibody, GTF3C2 antibody, MGC155253 antibody, TF3C-beta antibody, DKFZp469M0113 antibody, 1300004C11Rik antibody, 2610510G03Rik antibody, AI225816 antibody, AU041069 antibody, mKIAA0011 antibody, TFIIIC-BETA antibody, general transcription factor IIIC subunit 2 antibody, general transcription factor IIIC, polypeptide 2, beta antibody, Gtf3c2 antibody, GTF3C2 antibody

Background: Background: General transcription factor 3C polypeptide 2 (GTF3C2/TFIIIC110) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. The functional contribution of GTF3C2/TFIIIC110 to the TFIIIC complex has not been fully determined. TFIIIC that is not associated with GTF3C2/TFIIIC110 has been purified, and it has been proposed that GTF3C2/TFIIIC110 functions to activate the TFIIIC complex for RNA polymerase III transcription. Recent studies argue against this model of GTF3C2/TFIIIC110 function.

Gene ID: 2976

NCBI Accession: NP_001512

UniProt: Q8WUA4