NCOA1 antibody (AA 600-650)
Quick Overview for NCOA1 antibody (AA 600-650) (ABIN7454614)
Target
See all NCOA1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
-
-
Binding Specificity
- AA 600-650
-
Purpose
- Rabbit anti-SRC1 Antibody, Affinity Purified
-
Purification
- Affinity Purified
-
Immunogen
- between AA 600 and 650
-
Isotype
- IgG
-
-
-
-
Application Notes
-
IHC: 1:500 - 1:2,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
-
Restrictions
- For Research Use only
-
-
-
Concentration
- 1000 μg/mL
-
Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
Preservative
- Sodium azide
-
Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Storage
- 4 °C
-
Expiry Date
- 12 months
-
-
- NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
-
Alternative Name
- SRC1
-
Background
- Background: Steroid receptor coactivator 1 (SRC1) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC1contains histone acetyltransferase (HAT) activities and may facilitate transcription through chromatin remodeling. SRCs associate with p300/CBP-associated factor and CREB binding protein (CBP) as part of a multisubunit coactivating complex.
-
Gene ID
- 8648
-
NCBI Accession
- NP_003734
-
UniProt
- Q15788
-
Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
Target
-