General Transcription Factor 3C Polypeptide 3 (GTF3C3) (AA 475-525) antibody

Catalog No. ABIN7454731

The Rabbit Polyclonal anti-General Transcription Factor 3C Polypeptide 3 antibody is suitable to detect General Transcription Factor 3C Polypeptide 3 in samples from Human. It has been validated for IP, IHC (fp) and WB.

Quick Overview for General Transcription Factor 3C Polypeptide 3 (GTF3C3) (AA 475-525) antibody (ABIN7454731)

Target: General Transcription Factor 3C Polypeptide 3 (GTF3C3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Western Blotting (WB)

Product Details

Binding Specificity: AA 475-525

Purpose: Rabbit anti-GTF3C3/TFIIIC102 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 475 and 525

Isotype: IgG

Application Details

Application Notes:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details

Target: General Transcription Factor 3C Polypeptide 3 (GTF3C3)

Alternative Name: GTF3C3/TFIIIC102

Background: Background: General transcription factor 3C polypeptide 3 (GTF3C3/TFIIIC102) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. GTF3C3/TFIIIC102 appears to be important for stable complex formation and recruitment of RNA polymerase III by interacting with TFIIIB90, TBP, and TFIIIC63. GTF3C3/TFIIIC102 has been shown to also interact with DEDD and FLAME-3 proteins. This interaction may function to translocate GTF3C3/TFIIIC102 to the nucleus and regulate TFIIIC activity.

Gene ID: 9330

NCBI Accession: NP_036218

UniProt: Q9Y5Q9