Recombinant TP53BP1 antibody (AA 350-400)

Catalog No. ABIN7455070

The Rabbit Monoclonal anti-TP53BP1 antibody has been validated for WB, IP and IHC (fp). It is suitable to detect TP53BP1 in samples from Human and Mouse.

Quick Overview for Recombinant TP53BP1 antibody (AA 350-400) (ABIN7455070)

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TP53BP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: BL-250-1H11

Product Details anti-TP53BP1 Antibody

Binding Specificity: AA 350-400

Purpose: Rabbit anti-53BP1 Recombinant Monoclonal Antibody [BL-250-1H11]

Immunogen: between AA 350 and 400

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 20 μL/mg lysate

WB: 17:40:00

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TP53BP1

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Alternative Name: 53BP1

Background: Background: 53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.

Gene ID: 7158

NCBI Accession: NP_005648

UniProt: Q12888

Pathways: DNA Damage Repair