Poliovirus Receptor antibody (N-Term)

Catalog No. ABIN7464690

This Rabbit Polyclonal antibody specifically detects Poliovirus Receptor in WB. It exhibits reactivity toward Human.

Quick Overview for Poliovirus Receptor antibody (N-Term) (ABIN7464690)

Target: Poliovirus Receptor (PVR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Poliovirus Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Grade: KO Validated

Product Details anti-Poliovirus Receptor Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human CD155. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: K562 , THP-1 , HL-60 , 293T

Validation: KO/KD

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Alternative Name: poliovirus receptor

Background: Poliovirus receptor , CD155 , HVED , NECL5 , Necl-5 , PVS , TAGE4,The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Molecular Weight: 45 kDa

Gene ID: 5817

UniProt: P15151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome