NLRC4 antibody (N-Term)

Catalog No. ABIN7466246

The Mouse Monoclonal anti-NLRC4 antibody (Clone GT1387) (ABIN7466246) specifically detects NLRC4 in WB. The antibody is reactive with Human samples.

Quick Overview for NLRC4 antibody (N-Term) (ABIN7466246)

Target: NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NLRC4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: GT1387

Product Details anti-NLRC4 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human

Purification: Affinity purified by Protein A.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human CARD12. The exact sequence is proprietary.

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: human NLRC4-transfected 293T cells

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for NLRC4

Target: NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))

Alternative Name: NLR family CARD domain containing 4

Background: NLR family CARD domain containing 4 , AIFEC , CARD12 , CLAN , CLAN1 , CLANA , CLANB , CLANC , CLAND , CLR2.1 , FCAS4 , IPAF,This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Molecular Weight: 116 kDa

Gene ID: 58484

UniProt: Q9NPP4

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome