NCOA1 antibody (AA 477-947)

Catalog No. ABIN7466744

The Mouse Monoclonal anti-NCOA1 antibody (Clone 1135) (ABIN7466744) specifically detects NCOA1 in WB, IP and ChIP. The antibody is reactive with Human samples.

Quick Overview for NCOA1 antibody (AA 477-947) (ABIN7466744)

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NCOA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

Clone: 1135

Product Details anti-NCOA1 Antibody

Binding Specificity: AA 477-947

Cross-Reactivity: Human, Monkey, Mouse, Rat

Purification: Protein G purified

Immunogen: Amino acids 477-947 of human SRC-1.

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:3000. IP: 0.5 - 2 μg/mL. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: mouse brain

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for NCOA1

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Alternative Name: nuclear receptor coactivator 1

Background: Nuclear receptor coactivator 1 , F-SRC-1 , KAT13A , RIP160 , SRC1 , bHLHe42 , bHLHe74,The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Molecular Weight: 157 kDa

Gene ID: 8648

UniProt: Q15788

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha