ATP2B3 antibody (C-Term)

Catalog No. ABIN7468011

Product Details anti-ATP2B3 Antibody

Target: ATP2B3 (ATPase, Ca++ Transporting, Plasma Membrane 3 (ATP2B3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP2B3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ATP2B3 / PMCA3 ATPase. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: U87-MG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for ATP2B3

Target: ATP2B3 (ATPase, Ca++ Transporting, Plasma Membrane 3 (ATP2B3))

Alternative Name: ATPase plasma membrane Ca2+ transporting 3 (ATP2B3 Products)

Synonyms: PMCA3 antibody, PMCA3a antibody, SCAX1 antibody, atp2b3 antibody, pmca3a antibody, zgc:92885 antibody, 6430519O13Rik antibody, Pmca3 antibody, ATPase plasma membrane Ca2+ transporting 3 antibody, ATPase, Ca++ transporting, plasma membrane 3a antibody, ATPase, Ca++ transporting, plasma membrane 3 antibody, plasma membrane calcium-transporting ATPase 2 antibody, ATP2B3 antibody, atp2b3a antibody, Atp2b3 antibody, atp2b3 antibody, LOC100639471 antibody

Background:

Synonyms: ATPase plasma membrane Ca2+ transporting 3 , CFAP39 , CLA2 , OPCA , PMCA3 , PMCA3a , SCAX1

Background: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Molecular Weight: 134 kDa

Gene ID: 492

UniProt: Q16720

Pathways: Ribonucleoside Biosynthetic Process