Recombinant TNFRSF10B antibody

Catalog No. ABIN7487721

The Human Monoclonal anti-TNFRSF10B antibody is suitable to detect TNFRSF10B in samples from Human. It has been validated for ELISA and RIA.

Quick Overview for Recombinant TNFRSF10B antibody (ABIN7487721)

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Human

Clonality: Monoclonal

Conjugate: This TNFRSF10B antibody is un-conjugated

Application: ELISA, Radioimmunoassay (RIA)

Clone: 304

Product Details anti-TNFRSF10B Antibody

Purpose: Anti-DR5 [304], Human IgG4-S228P, kappa

Specificity:

The antibody is specific to human DR5.

Application Notes original Clone: This antibody has shown high anti-tumour activity in mice with subcutaneously transplanted colon carcinoma cells Colo205. It has tumour-specific cell-death-inducing activity alone in tissue culture so is expected to show anti-tumour activity independent of physiological conditions of the patient. The antibody has been shown to function in ELISA and RIA.

Characteristics: This reformatted human antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Purification: Protein A affinity purified

Immunogen: The antibody was raised in mice homozygous for both disrupted endogenous Ig heavy chain and k light chain, harboring a chromosome 14 fragment (SC20) containing a human Ig heavy chain locus and a human Igk chain transgene (KCo5). The mice were immunised against TRAIL-R1 and TRAIL-R2.

Isotype: IgG4, S228P, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

OriginalSpeciesName: Human

OriginalFormat: IgG4

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Alternative Name: DR5

Background: TRAILR2, TNFRSF10B, TRAIL receptor 2, tumor necrosis factor receptor superfamily member 10B

UniProt: O14763

Pathways: p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity