PPM1D antibody

Catalog No. ABIN7506006

This Mouse Monoclonal antibody specifically detects PPM1D in WB, ELISA, IHC (p), ICC and ICFC. It exhibits reactivity toward Human and Mouse.

Quick Overview for PPM1D antibody (ABIN7506006)

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPM1D antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Intracellular Flow Cytometry (ICFC)

Clone: 7E11-C5

Product Details anti-PPM1D Antibody

Purpose: Anti-PPM1D Purified

Specificity: The mouse monoclonal antibody 7E11/C5 recognizes an epitope within the sequence FTNEDELYNLLTDSP of PPM1D, a protein phosphatase, which contributes to development of some carcinomas.

Purification: Purified by protein-A affinity chromatography.

Immunogen: Purified human PPM1D

Isotype: IgG1

Application Details

Application Notes: Western blotting: Recommended dilution: 1-2 μg/mL.
Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for PPM1D

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Alternative Name: PPM1D

Background: Protein phosphatase, Mg2+/Mn2+ dependent 1D,PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer.,WIP1, Protein phosphatase 1D, JDVS, WIP1, IDDGIP

Gene ID: 8493

UniProt: O15297

Pathways: p53 Signaling, Cell Division Cycle