beta-2 Microglobulin antibody (AA 21-119)

Catalog No. ABIN7538095

The Rabbit Polyclonal anti-beta-2 Microglobulin antibody (ABIN7538095) specifically detects beta-2 Microglobulin in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for beta-2 Microglobulin antibody (AA 21-119) (ABIN7538095)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-beta-2 Microglobulin Antibody

Binding Specificity: AA 21-119

Purpose: Rabbit polyclonal antibodies to Beta-2-Microglobulin

Specificity: Beta-2-microglobulin

Cross-Reactivity (Details): May cross-react with other species

Purification: Immunogen affinity column

Immunogen: B2MG_Human 21-119 

Isotype: IgG, IgM

Application Details

Application Notes: Western blot: 0.1-1.0 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Glycine pH 7.2

Storage: 4 °C,-80 °C

Storage Comment: Short term up to 1 month at 2-8°C, long term can be held for up to five years at -70°C

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: Beta-2-Microglobulin

Background: Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

Molecular Weight: 11731 Da

Gene ID: 567

NCBI Accession: NP_004039

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process