EPH Receptor A7 antibody (AA 181-280) (Biotin)

Catalog No. ABIN722007

This anti-EPH Receptor A7 antibody is a Rabbit Polyclonal antibody detecting EPH Receptor A7 in WB, ELISA, IHC (p), IHC (fro). Suitable for Human, Rat, Mouse.

Quick Overview for EPH Receptor A7 antibody (AA 181-280) (Biotin) (ABIN722007)

Target: EPH Receptor A7 (EPHA7)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A7 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-EPH Receptor A7 Antibody (Biotin)

Binding Specificity: AA 181-280

Specificity: There is a chance that this protein will cross-react with EphA4 based on a 73 % non-sequential sequence similarity.

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EphA7

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for EPH Receptor A7

Target: EPH Receptor A7 (EPHA7)

Alternative Name: EphA7

Background:

Synonyms: EHK3, EK11, EHK-3, HEK11, Ephrin type-A receptor 7, EPH homology kinase 3, EPH-like kinase 11, EPHA7

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Gene ID: 2045

UniProt: Q15375

Pathways: RTK Signaling