EPH Receptor A7 antibody (pTyr791)

Catalog No. ABIN7139071

Product Details anti-EPH Receptor A7 Antibody

Target: EPH Receptor A7 (EPHA7)

Binding Specificity: pTyr791

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 791 (A-V-Y(p)-T-T) derived from Human EPHA7 .

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EPH Receptor A7

Target: EPH Receptor A7 (EPHA7)

Alternative Name: EPHA7 (EPHA7 Products)

Synonyms: fc51g03 antibody, wu:fc51g03 antibody, si:dkey-23k6.1 antibody, EHK3 antibody, HEK11 antibody, Cek11 antibody, Ebk antibody, Ehk3 antibody, Hek11 antibody, Mdk1 antibody, CEPHA7 antibody, EPH receptor A7 antibody, eph receptor A7 antibody, ephrin type-B receptor 1-B antibody, Eph receptor A7 antibody, EPHA7 antibody, epha7 antibody, LOC100166161 antibody, Epha7 antibody

Background:

Background:

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus.

Fox G.M., Oncogene 10:897-905(1995).
Mungall A.J., Nature 425:805-811(2003).

Aliases: Cek 11 antibody, Developmental kinase 1 antibody, EBK antibody, EHK-3 antibody, EHK3 antibody, EK11 antibody, Embryonic brain kinase antibody, EPH homology kinase 3 antibody, EPH-like kinase 11 antibody, Epha7 antibody, EPHA7_HUMAN antibody, Ephrin receptor Eph A7 antibody, Ephrin type A receptor 7 antibody, Ephrin type-A receptor 7 antibody, hEK11 antibody, MDK 1 antibody, Receptor protein tyrosine kinase HEK 11 antibody, Tyrosine protein kinase receptor EHK 3 antibody

UniProt: Q15375

Pathways: RTK Signaling