APP antibody

Catalog No. ABIN7539630

This Mouse Monoclonal antibody specifically detects APP in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for APP antibody (ABIN7539630)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 1B11F3

Product Details anti-APP Antibody

Purpose: APP Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of APP expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: APP

Background: Amyloid precursor protein(APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation of haemostasis and mediation of neuroprotection. APP undergoes alternative splicing, resulting in several isoforms . Proteolytic cleavage of amyloid precursor protein leads to the formation of the 4 kDa amyloid beta/A4 protein, which is present in human platelets. APP is also involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients.

Gene ID: 351

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour