XPC antibody (AA 32-133)

Catalog No. ABIN7539756

This Mouse Monoclonal antibody specifically detects XPC in WB, ELISA, IHC, FACS and ICC. It exhibits reactivity toward Human.

Quick Overview for XPC antibody (AA 32-133) (ABIN7539756)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This XPC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 5F4D3

Product Details anti-XPC Antibody

Binding Specificity: AA 32-133

Purpose: XPC Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human XPC (AA: 32-133) expressed in mammalian.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50 - 1/200

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC

Background: The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight: 106 kDa

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair