Recombinant GRIN2B antibody

Catalog No. ABIN7543081

The Rabbit Chimeric anti-GRIN2B antibody (Clone 17) (ABIN7543081) specifically detects GRIN2B in Crys. The antibody is reactive with Rat samples.

Quick Overview for Recombinant GRIN2B antibody (ABIN7543081)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Antibody Type: Recombinant Antibody

Reactivity: Rat

Host: Rabbit

Clonality: Chimeric

Conjugate: This GRIN2B antibody is un-conjugated

Application: Crystallization (Crys)

Clone: 17

Product Details anti-GRIN2B Antibody

Purpose: Anti-NMDA Receptor [17], Rabbit IgG, kappa

Specificity: Reacts specifically with rat GluN2B ATD.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG

Purification: Protein A affinity purified

Immunogen: Monoclonal antibodies that bind rat GluN2B ATD were obtained by immunizing mice with the purified intact GluN1-GluN2B NMDA receptors. IgGs were purified from hybridoma cell culture supernatant by Protein-A Sepharose. Fab fragments have been prepared by papain proteolysis followed by re-chromatographing onto Protein-A Sepharose to remove Fc.

Isotype: IgG kappa

Application Details

Application Notes: This antibody has been used for the crystallisation of the NMDA receptor in the absence of an allosteric inhibitor at 2.9A (Tajima 2016).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Alternative Name: Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B

Background: NMDAR, NMDA-R, Glutamate receptor

UniProt: Q00960

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity