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Insulin antibody (FITC)

This Mouse Monoclonal antibody specifically detects Insulin in IF (p) and IF (cc). It exhibits reactivity toward Humanand has been mentioned in 1 publication.
Catalog No. ABIN722608

Quick Overview for Insulin antibody (FITC) (ABIN722608)

Target

See all Insulin (INS) Antibodies
Insulin (INS)

Reactivity

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  • 93
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  • 44
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  • 1
  • 1
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  • 1
Human

Host

  • 152
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  • 13
  • 1
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Mouse

Clonality

  • 162
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  • 1
Monoclonal

Conjugate

  • 157
  • 23
  • 14
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  • 5
  • 5
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  • 4
  • 4
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  • 2
  • 2
  • 2
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  • 2
  • 2
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  • 1
  • 1
This Insulin antibody is conjugated to FITC

Application

  • 118
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  • 82
  • 69
  • 67
  • 57
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  • 47
  • 38
  • 17
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Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone

1G11
  • Cross-Reactivity

    Human

    Purification

    Purified by Protein G.

    Immunogen

    Recombinant human Insulin protein

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Zöllner, Jouni, Panzer, Khadour, Janzen, Wesche, Ten Berg, Schellong, Heinken, Greinacher, Bakchoul: "Platelet activation in the presence of neutral protamine Hagedorn insulin: a new feature of antibodies against protamine/heparin complexes." in: Journal of thrombosis and haemostasis : JTH, (2016) (PubMed).

  • Target

    Insulin (INS)

    Alternative Name

    Insulin

    Background

    Synonyms: ILPR, INS, Insulin A chain, Insulin B chain, Insulin A chain, Insulin precursor, IRDN, Proinsulin, Proinsulin precursor, IDDM2, INS_HUMAN, MODY10.

    Background: Insulin is a pancreatic hormone that regulates glucose and is involved in the synthesis of protein and fat. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I and IGF-II (also desinated somatomedin C and multiplication stimulating activator, respectvely), share approximatly 76 % sequence identity and are 50 % related to pro-insulin.IGF-I and IGF-II are nonglycosylated, single chain proteins of 70 and 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined.

    Gene ID

    3630

    Pathways

    NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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