Serotonin Receptor 6 antibody (Extracellular, Loop 2)

Catalog No. ABIN7887157

This Rabbit Polyclonal antibody specifically detects Serotonin Receptor 6 in WB and IHC. It exhibits reactivity toward Rat.

Quick Overview for Serotonin Receptor 6 antibody (Extracellular, Loop 2) (ABIN7887157)

Target: Serotonin Receptor 6 (HTR6)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Serotonin Receptor 6 Antibody

Binding Specificity: AA 167-181, Extracellular, Loop 2

Purpose: A Rabbit Polyclonal antibody to 5HT6 Receptor (HTR6) (extracellular).

Sequence: (C)HELGKARTPA PGQ(S)R

Predicted Reactivity: Rat - 14 out of 15 amino acid residues identical Mouse - 13 out of 15 amino acid residues identical The antibody is not recommended for human samples

Characteristics: Anti-5HT6 Receptor (HTR6) (extracellular) Antibody (ABIN7581901) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize 5HT6 from mouse and rat samples. The antibody is not recommended for human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)HELGKARTPAPGQ(S)R, corresponding to amino acid residues 167 - 181 of rat HTR6

Isotype: IgG

Application Details

Application Notes:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Serotonin Receptor 6

Target: Serotonin Receptor 6 (HTR6)

Alternative Name: HTR6

Background:

Synonyms: 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, 5-HT-6, 5HT6R

Description: 5HT6 also known as 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, or 5-HT-6, is a member of the serotonin (5-HT) family of receptors that comprises 14 members, classified into 7 distinct families (5HT1 to 5HT7). With the exception of 5HT3 that is a ligand-gated channel, all other family members are G protein-coupled receptors (GPCRs) 1,2.The 5HT6 receptor is almost exclusively present in the central nervous system and is distributed in various brain regions, including the striatum, nucleus accumbens, hippocampus, thalamus, cerebellum, dentate gyrus, olfactory tubercles, amygdala, and cerebral cortex.1,2,5Based on the unique expression pattern of 5HT6 in the brain, research on the 5HT6 receptor has suggested its involvement in various neurological and psychiatric conditions, including mood disorders, schizophrenia, cognitive function and Alzheimer's disease 1,2,5. Indeed several antagonists of 5HT6 receptor have been examined in the context of schizophrenia3, Alzheimer's disease4 and cognitive impairment 5.

Gene ID: 64354

UniProt: P31388

Pathways: JAK-STAT Signaling