LSM2 antibody (AA 1-95)

Catalog No. ABIN7596084

This Mouse Monoclonal antibody specifically detects LSM2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for LSM2 antibody (AA 1-95) (ABIN7596084)

Target: LSM2 (LSM2 Homolog, U6 Small Nuclear RNA Associated (LSM2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LSM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: AT1G7

Product Details anti-LSM2 Antibody

Binding Specificity: AA 1-95

Purpose: Human LSM2 antibody

Purification: protein-A affinity chromatography

Immunogen: Recombinant human LSm2 (1-95aa) purified from E. coli

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details for LSM2

Target: LSM2 (LSM2 Homolog, U6 Small Nuclear RNA Associated (LSM2))

Alternative Name: LSM2

Background: LSM2 is a member of the LSm family of RNA-binding proteins. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic complex which is thought to be involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2 complex, which is involved in splicing of nuclear mRNAs. LSM2 associates with multiple snRNP complexes containing the U6 snRNA It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.

NCBI Accession: NP_067000

Pathways: Ribonucleoprotein Complex Subunit Organization