CDKN1C antibody (N-Term)

Catalog No. ABIN7603232

This anti-CDKN1C antibody is a Rabbit Polyclonal antibody detecting CDKN1C in WB and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for CDKN1C antibody (N-Term) (ABIN7603232)

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN1C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CDKN1C Antibody

Binding Specificity: N-Term

Purpose: Anti-p57 Kip2/CDKN1C Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-p57 Kip2/CDKN1C Antibody Picoband® (ABIN7603232). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human p57 Kip2/CDKN1C, identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
1. Algar, E., Brickell, S., Deeble, G., Amor, D., Smith, P. Analysis of CDKN1C in Beckwith Wiedemann syndrome. Hum. Mutat. 15: 497-508, 2000. 2. Algar, E. M., Deeble, G. J., Smith, P. J. CDKN1C expression in Beckwith-Wiedemann syndrome patients with allele imbalance. J. Med. Genet. 36: 524-531, 1999. 3. Arboleda, V. A., Lee, H., Parnaik, R., Fleming, A., Banerjee, A., Ferraz-de-Souza, B., Delot, E. C., Rodriguez-Fernandez, I. A., Braslavsky, D., Bergada, I., Dell'Angelica, E. C., Nelson, S. F., Martinez-Agosto, J. A., Achermann, J. C., Vilain, E. Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome. Nature Genet. 44: 788-792, 2012.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for CDKN1C

Target: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))

Alternative Name: CDKN1C

Background:

Synonyms: Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2

Tissue Specificity: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

Background: Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. It is mapped to 11p15.4. This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

Molecular Weight: 30 kDa

Gene ID: 1028

UniProt: P49918

Pathways: Cell Division Cycle, Dopaminergic Neurogenesis