ErbB2/Her2 antibody

Catalog No. ABIN8062515

The Mouse Monoclonal anti-ErbB2/Her2 antibody (Clone SER4) (ABIN8062515) specifically detects ErbB2/Her2 in FACS. The antibody is reactive with Human samples.

Quick Overview for ErbB2/Her2 antibody (ABIN8062515)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: SER4

Product Details anti-ErbB2/Her2 Antibody

Purpose: Purified Anti-Human CD340 Antibody[SER4]

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: CD340

Background: TKR,ERBB,erb-b2 receptor tyrosine kinase,Receptor tyrosine-protein kinase erbB,Tyrosine kinase-type cell surface receptor HER,HER2/ErbB,HER,MLN,ERBB2,CD340,HER-2,HER-2/neu,HER2,MLN 19,NEU,NGL,TKR1,erb-b2 receptor tyrosine kinase 2,HER2/ErbB2,MLN19,Metastatic lymph node gene 19 protein,p185,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosine kinase-type cell surface receptor HER2, Neu, erb-B2,CD340,erb-b2 receptor tyrosine kinase 2,HER2,HER-2,HER-2/neu,MLN 19,MLN19,NGL,TKR1,C erb B2/neu protein,CD340 antigen,Cerb B2/neu protein,CerbB2,ENV,ENVW,Erb b2 receptor tyrosine kinase 2,ERVWE1,HER 2,HER 2/NEU,Herstatin,HERV7Q,HERV-7q,HERVW,HERVWENV,HERV-W-ENV,Human epidermal growth factor receptor 2,NEU proto oncogene,neuro/glioblastoma derived oncogene homolog,neuro/glioblastoma derived oncogene homolog (avian),Neuroblastoma/glioblastoma derived oncogene homolog,p185erbB2,Proto-oncogene c-ErbB-2,Tyrosine kinase type cell surface receptor HER2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),V erb b2 avian erythroblastic leukemia viral oncoprotein 2,V erb b2 erythroblastic leukemia viral oncogene homolog 2,Verb b2 erythroblastic leukemia viral oncogene homolog 2,ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1, heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

UniProt: P04626

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development