DPP4 antibody

Catalog No. ABIN7670590

This anti-DPP4 antibody is a Rabbit Polyclonal antibody detecting DPP4 in ELISA. Suitable for Human.

Quick Overview for DPP4 antibody (ABIN7670590)

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPP4 antibody is un-conjugated

Application: ELISA

Product Details anti-DPP4 Antibody

Purpose: DPPIV/CD26 Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Human DPPIV/CD26 protein expressed by Mammalian

Isotype: IgG

Application Details

Application Notes: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for DPP4

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Alternative Name: DPPIV/CD26

Background: Dipeptidyl peptidase 4,ADABP,Adenosine deaminase complexing protein 2 (ADCP-2),Dipeptidyl peptidase IV (DPP IV),T-cell activation antigen CD26,TP103,CD26,DPP4,ADCP2,CD26,CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. CD26 is expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. It acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It's binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. It may be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, it enhanced cell proliferation, a process inhibited by GPC3. It acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones.

UniProt: P27487

Pathways: Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity