IFNA1 antibody

Catalog No. ABIN7670652

The Rat Monoclonal anti-IFNA1 antibody is suitable to detect IFNA1 in samples from Mouse. It has been validated for ELISA (Capture).

Quick Overview for IFNA1 antibody (ABIN7670652)

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IFNA1 antibody is un-conjugated

Application: ELISA (Capture)

Clone: 7B2

Product Details anti-IFNA1 Antibody

Purpose: IFN-alpha 1 Monoclonal Antibody(Capture)

Purification: Protein A/G Purification

Immunogen: Recombinant Mouse IFN-alpha 1 protein expressed by Mammalian

Isotype: IgG2a

Application Details

Application Notes: ELISA Capture 2-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for IFNA1

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Alternative Name: IFN-alpha 1

Background: Ifna,IL-1ra Homolog,IFN-α,IL-1F,IL-1L,IL-1HY,IL-1RP,IFN-alpha,FIL1 delta,IFN-alpha-1,IFN-α1,IL-1 delta,IL-1F5,IL-1HY1,IL-1L1,IL-1ra Homolog 1,IL-1RP3,Ifna1,The interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, and classified based on their binding specificity to cell surface receptors. The type I IFN bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 ( alpha -subunit) and IFNAR2 ( beta -subunit). This binding contributes to TNF-alpha induced signaling. Both the human and mouse genome code for more than a dozen closely related IFNa subtypes and the varous IFN a share about 80 % sequence homology among them. Interferon-alpha 1 (IFNA1) is a secreted, approximately 19 kDa member of the type I interferon family of molecules. Mature mouse IFN-alpha 1 shares 63 % and 82 % amino acid sequence identity with human and rat IFN-alpha 1, respectively. Low level IFN-alpha is detected under physiological conditions, and the production of IFNs is markedly enhanced during virus infection. Although originally discovered by its capability to fight virus replication, IFN-alpha functions as a prototypic tumor suppressor that represses the clinical tumorigenic phenotype in some malignancies.

UniProt: P01572

Pathways: JAK-STAT Signaling, Hepatitis C