Haptoglobin antibody (AA 251-350) (Cy5.5)
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- Target See all Haptoglobin (HP) Antibodies
- Haptoglobin (HP)
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Binding Specificity
- AA 251-350
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Haptoglobin antibody is conjugated to Cy5.5
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Specificity
- This protein may interact with Peptidase S1 Domain in LPA.
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Hpt
- Isotype
- IgG
- Top Product
- Discover our top product HP Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Haptoglobin (HP)
- Abstract
- HP Products
- Synonyms
- HP antibody, wu:fb64e01 antibody, BP antibody, HP2ALPHA2 antibody, HPA1S antibody, HP-1 antibody, HPR antibody, Zonulin antibody, haptoglobin antibody, haptoglobin-like antibody, HP antibody, hp antibody, Hp antibody, LOC479668 antibody, LOC101102413 antibody
- Background
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Synonyms: BP, HPA1S, HP2ALPHA2, Haptoglobin, Zonulin, HP
Background: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
- Gene ID
- 3240
- UniProt
- P00738
- Pathways
- Transition Metal Ion Homeostasis
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