KCNH2 antibody (AA 1001-1159)

Catalog No. ABIN734843

There is 1 publication for this product available. The Rabbit Polyclonal anti-KCNH2 antibody is suitable to detect KCNH2 in samples from Human and Rat. It has been validated for ELISA, FACS and ICC.

Quick Overview for KCNH2 antibody (AA 1001-1159) (ABIN734843)

Target: KCNH2 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNH2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Product Details anti-KCNH2 Antibody

Binding Specificity: AA 1001-1159

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HERG

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
FCM 1:20-100
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-KCNH2 antibody (ABIN734843)

Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: "Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications." in: Basic research in cardiology, Vol. 109, Issue 5, pp. 427, (2014) (PubMed).

Target Details for KCNH2

Target: KCNH2 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2))

Alternative Name: KCNH2

Background:

Synonyms: ERG1, HERG, LQT2, SQT1, ERG-1, H-ERG, HERG1, Kv11.1, Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, Eag-related protein 1, Ether-a-go-go-related protein 1, hERG-1, Voltage-gated potassium channel subunit Kv11.1, KCNH2, ERG

Background: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.

Gene ID: 3757

UniProt: Q12809