Crlr/Cgrpr1 (AA 281-380) antibody

Catalog No. ABIN735503

Product Details

Target: Crlr/Cgrpr1

Binding Specificity: AA 281-380

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CGRPR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Ragauskas, Rysevaite-Kyguoliene, Pauziene, Inokaitis, Pauza: "Chemical phenotypes of intrinsic cardiac neurons in the newborn pig (Sus scrofa domesticus Erxleben, 1777)." in: Journal of morphology, Vol. 283, Issue 1, pp. 51-65, (2021) (PubMed).

Toriyama, Iesato, Imai, Sakurai, Kamiyoshi, Ichikawa-Shindo, Kawate, Yamauchi, Igarashi, Tanaka, Liu, Xian, Zhai, Owa, Murata, Shindo: "Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases." in: The American journal of pathology, Vol. 185, Issue 6, pp. 1783-94, (2015) (PubMed).

Jablonski, Kauther, Bachmann, Jäger, Wedemeyer: "Calcitonin Gene-Related Peptide Modulates the Production of Pro-Inflammatory Cytokines Associated with Periprosthetic Osteolysis by THP-1 Macrophage-Like Cells." in: Neuroimmunomodulation, Vol. 22, Issue 3, pp. 152-65, (2015) (PubMed).

Target Details

Target: Crlr/Cgrpr1

Background:

Synonyms: CRLR, CGRPR, Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL

Background: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene ID: 10203

UniProt: Q16602