Recombinant RUNX3 antibody

Catalog No. ABIN7828537

This Rabbit Monoclonal antibody specifically detects RUNX3 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Recombinant RUNX3 antibody (ABIN7828537)

Target: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RUNX3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: A518

Product Details anti-RUNX3 Antibody

Purpose: Recombinant RUNX3 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human RUNX3 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000,IP 1:25-1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for RUNX3

Target: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Alternative Name: RUNX3

Background: AML,RUNX,CBFA,Oncogene AML,Core-binding factor subunit alpha,Runt-related transcription factor,PEBP2A,RUNX3,AML2,CBFA3,PEBP2aC,Acute myeloid leukemia 2 protein,Core-binding factor subunit alpha-3,Oncogene AML-2,Runt-related transcription factor 3,PEBP2A3,RUNX3 is a member of the Runt family of transcription factors, playing an important role in the suppression of gastric epithelium cell proliferation, dorsal root ganglia neurogenesis, and T cell differentiation. RUNX3 is also involved in Caspase-3-dependent apoptosis. Protein complexes containing RUNX3 and various transcription factors, such as Smads or β-catenin/TCF4, have tumor suppressor activity and regulate downstream target gene transcription. While typically localized to the nucleus, RUNX3 can be tyrosine phosphorylated and located in the cytoplasm of many cancer cells. This mislocalization of RUNX3 abolishes its tumor suppressor function and contributes to tumorigenesis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 46 kDa

Observed MW: 44-46 kDa The actual band is not consistent with the expectation.

UniProt: Q13761