TTR antibody

Catalog No. ABIN7833608

The Mouse Monoclonal anti-TTR antibody (ABIN7833608) specifically detects TTR in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for TTR antibody (ABIN7833608)

Target: TTR (Transthyretin (TTR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-TTR Antibody

Purpose: Anti-Transthyretin 56-61, amyloid specific (mouse monoclonal)

Cross-Reactivity (Details): Human Transthyretin Amyloids
Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Purification: Affinity purified

Immunogen: Recombinant protein corresponding to the Human wild type Transthyretin. GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE The epitope has been mapped to residue 56-61

Isotype: IgG1

Application Details

Application Notes: 1:1000 (ELISA), 1:500 (IHC), 1:1000 (WB)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 μL sterile water to reconstitute to 1 mg/mL

Buffer: Affinity purified in PBS pH 7.4.

Handling Advice: Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube

Storage: 4 °C

Storage Comment: Store lyophilized/reconstituted at 4°C, Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: Transthyretin 56-61

Background: Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 10 % of the population above 80 years of age with depositions mainly found in the heart.Monoclonal IgG1 antibody. Amyloid specific for human Transthyretin. Detects the C-terminal fragment 49-127 frequently formed in vivo.

Molecular Weight: 155

Pathways: Hormone Transport