KISS1R antibody (AA 121-200)

Catalog No. ABIN741180

Product Details anti-KISS1R Antibody

Target: KISS1R (KISS1 Receptor (KISS1R))

Binding Specificity: AA 121-200

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KISS1R antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Sheep,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KiSS1 receptor

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-KISS1R antibody (ABIN741180)

Luo, Li, Li, Zhang, Zhang: "Leptin/leptinR-kisspeptin/kiss1r-GnRH pathway reacting to regulate puberty onset during negative energy balance." in: Life sciences, Vol. 153, pp. 207-12, (2016) (PubMed).

Luo, Hou, Yin, Zhang: "Expression of kisspeptin/kiss1r system in developing hypothalamus of female rat and the possible effects on reproduction development and maintenance." in: Journal of the Chinese Medical Association : JCMA, Vol. 79, Issue 10, pp. 546-53, (2016) (PubMed).

Target Details for KISS1R

Target: KISS1R (KISS1 Receptor (KISS1R))

Alternative Name: Kiss1 Receptor (KISS1R Products)

Synonyms: AXOR12 antibody, CPPB1 antibody, GPR54 antibody, HH8 antibody, HOT7T175 antibody, KISS-1R antibody, Gpr54 antibody, KiSS-1 antibody, gpr54 antibody, gpr54-1 antibody, gpr54a antibody, kiss1r antibody, kiss1rl antibody, kissr2 antibody, si:dkey-31m5.9 antibody, axor12 antibody, kissr1a antibody, KISS1 receptor antibody, KISS1 receptor a antibody, KISS1R antibody, Kiss1r antibody, kiss1ra antibody, kiss1r antibody

Background:

Synonyms: HH8, CPPB1, GPR54, AXOR12, KISS-1R, HOT7T175, KiSS-1 receptor, G-protein coupled receptor 54, G-protein coupled receptor OT7T175, Hypogonadotropin-1, Kisspeptins receptor, Metastin receptor, KISS1R

Background: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

Gene ID: 84634

UniProt: Q969F8