Recombinant Endoglin antibody

Catalog No. ABIN7865328

The Mouse Monoclonal anti-Endoglin antibody is suitable to detect Endoglin in samples from Human. It has been validated for WB and IHC.

Quick Overview for Recombinant Endoglin antibody (ABIN7865328)

Target: Endoglin (ENG)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: R4G11

Product Details anti-Endoglin Antibody

Expression System: CHO Cells

Purpose: Recombinant Endoglin / CD105 (Angiogenesis Marker) Antibody

Specificity: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant protein corresponding to a region of the external domain of the CD105 glycoprotein

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: Endoglin

Background:

CD105, END, Endoglin, Eng, HHT1, S-endoglin

HeLa, A431 or HL-60 cells. Human placenta or brain.

Molecular Weight: 80kDa (Monomer), 160kDa (Homodimer)

Gene ID: 2022, 76753

UniProt: P17813