Recombinant p40 (p63 Delta) (AA 1-100) antibody

Catalog No. ABIN7863562

The Rabbit Monoclonal anti-p40 (p63 Delta) antibody (Clone P40-4396R) (ABIN7863562) specifically detects p40 (p63 Delta) in IHC, FACS and ELISA. The antibody is reactive with Human samples.

Quick Overview for Recombinant p40 (p63 Delta) (AA 1-100) antibody (ABIN7863562)

Target: p40 (p63 Delta)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA

Clone: P40-4396R

Product Details

Binding Specificity: AA 1-100

Purpose: Recombinant p40 (Squamous, Basal & Myoepithelial Cell Marker) Antibody

Specificity: P40 antibody (antibody recognizing Np63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential a role that may be recapitulated in tumors derived from these cells. p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial), basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogen: Recombinant fragment (around aa1-100) of human p40 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details

Target: p40 (p63 Delta)

Alternative Name: p40

Background:

Amplified in squamous cell carcinoma (AIS), Chronic ulcerative stomatitis protein (CUSP), EEC3, TP73L, LMS, TP63, Keratinocyte transcription factor KET, NBP, P51/P63, p53 like transcription factor, RHS, SHFM4, TAp63alpha, TP53CP, TP53L, Transformation-related protein 63, Trp53rp1, Trp6,3, Tumor protein p53-like, tumor protein p73-like

HEK293, lung or bladder squamous cell carcinoma tissue., MDA-MB453 or MCF7 cells. Human prostate

Molecular Weight: 63kDa

Gene ID: 8626, 137569

UniProt: Q9H3D4