Recombinant p40 (p63 Delta) (AA 1-200) antibody

Catalog No. ABIN7857929

This Rabbit Monoclonal antibody specifically detects p40 (p63 Delta) in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant p40 (p63 Delta) (AA 1-200) antibody (ABIN7857929)

Target: p40 (p63 Delta)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Clone: P40-7302R

Product Details

Binding Specificity: AA 1-200

Purpose: Recombinant p40 (Squamous, Basal & Myoepithelial Cell Marker) Antibody

Specificity: P63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogen: Recombinant fragment (around aa1-200) of human TP63 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details

Target: p40 (p63 Delta)

Alternative Name: p40

Background:

Amplified in squamous cell carcinoma (AIS), Chronic ulcerative stomatitis protein (CUSP), EEC3, Keratinocyte transcription factor KET, LMS, NBP, p40, P51/P63, p53 like transcription factor, p53-related protein p63, RHS, SHFM4, TAp63alpha, TP53CP, TP53L, TP63, TP73, TP73L, Transformation-related protein 63, Trp53rp1, Trp6,3

HEK293, lung or bladder squamous cell carcinoma tissue., MDA-MB453 or MCF7 cells. Human prostate

Molecular Weight: 63kDa

Gene ID: 8626, 137569

UniProt: Q9H3D4