p40 (p63 Delta) (AA 1-50) antibody
Reactivity: Human
WB, IHC
Host: Mouse
Monoclonal
BC28
unconjugated
-
- Target
- p40 (p63 Delta)
- Binding Specificity
- AA 1-50
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purpose
- Mouse anti-p40 Monoclonal Antibody [BC28]
- Immunogen
- between AA 1 and 50
- Clone
- BC28
- Isotype
- IgG
-
anti-p40 (p63 Delta) (AA 5-17) antibody
Reactivity: Human, Cow, Mouse, Rat WB, FACS, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
-
- Application Notes
-
IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
WB: 17:40:00
- Restrictions
- For Research Use only
-
- Concentration
- 250 μg/mL
- Buffer
- Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Expiry Date
- 12 months
-
- Target
- p40 (p63 Delta)
- Alternative Name
- p40
- Synonyms
- AIS antibody, B(p51A) antibody, B(p51B) antibody, EEC3 antibody, KET antibody, LMS antibody, NBP antibody, OFC8 antibody, RHS antibody, SHFM4 antibody, TP53CP antibody, TP53L antibody, TP73L antibody, p40 antibody, p51 antibody, p53CP antibody, p63 antibody, p73H antibody, p73L antibody, tumor protein p63 antibody, TP63 antibody
- Background
- Background: Tumor protein p63 is a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. P63 is an extremely sensitive marker of lung squamous cell carcinoma, but it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types. P40 is a splice isoform of p63 known as DeltaNp63 and has been demonstrated to be highly specific for squamous/basal cells making it is markedly superior to p63 in specificity [adapted from NCBI Entrez Gene (Gene ID: 8626)].
- Gene ID
- 8626
- NCBI Accession
- NP_003713
- UniProt
- Q9H3D4
-
You are here:
