Tyrosinase-Related Protein 1 antibody (AA 200-400)

Catalog No. ABIN7857990

The Rabbit Monoclonal anti-Tyrosinase-Related Protein 1 antibody is suitable to detect Tyrosinase-Related Protein 1 in samples from Human. It has been validated for IHC.

Quick Overview for Tyrosinase-Related Protein 1 antibody (AA 200-400) (ABIN7857990)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TYRP1-8313R

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Binding Specificity: AA 200-400

Purpose: Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody

Specificity: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. 79oΩRecent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Purification: 200ug/ml of Ab purified by Protein A.

Immunogen: Recombinant fragment (around aa200-400) of human TYRP1 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: Tyrosinase-Related Protein-1

Background:

5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP

SK-MEL-19|SK-MEL-23|SK-MEL-30 or SK-MEL-37 cells. Human melanoma.

Molecular Weight: 75kDa

Gene ID: 7306, 270279

UniProt: P17643