IL-6 antibody (AA 1-200)

Catalog No. ABIN7858570

The Mouse Monoclonal anti-IL-6 antibody (Clone IL6-4642) (ABIN7858570) specifically detects IL-6 in IHC. The antibody is reactive with Human samples.

Quick Overview for IL-6 antibody (AA 1-200) (ABIN7858570)

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-6 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IL6-4642

Product Details anti-IL-6 Antibody

Binding Specificity: AA 1-200

Purpose: IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody

Specificity: IL-6 is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B-cells and T-cells. It plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6.It is involved in host defense, acute phase reactions, immune responses, and hematopoiesis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human IL-6 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for IL-6

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Alternative Name: IL-6

Background:

B-cell stimulatory factor 2 (BSF-2), CTL differentiation factor (CDF), Cytotoxic T cell differentiation factor, Hepatocyte stimulating factor (HSF), HPGF, Hybridoma growth factor Interferon beta-2, Hybridoma plasmacytoma growth factor, IFN-beta-2 (IFNB2)

Human heart or adrenal gland. Stimulated peritoneal macrophages.

Molecular Weight: 21kDa

Gene ID: 3569, 654458

UniProt: P05231

Pathways: TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome