PON1 antibody (AA 1-200)

Catalog No. ABIN7858656

The Mouse Monoclonal anti-PON1 antibody is suitable to detect PON1 in samples from Human. It has been validated for IHC.

Quick Overview for PON1 antibody (AA 1-200) (ABIN7858656)

Target: PON1 (Paraoxonase 1 (PON1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PON1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PON1-1351

Product Details anti-PON1 Antibody

Binding Specificity: AA 1-200

Purpose: PON1 / Paraoxonase 1 Antibody

Specificity: Paroxon is an organophosphorus anticholinesterase compound, used topically in the treatment of glaucoma. It is produced in vivo in mammals by microsomal oxidation of the insecticide parathion. Parathion is inert until transformed to paroxon. Paroxonase or PON is an arylesterase that is capable of hydrolyzing paroxon to produce p-nitrophenol. PONs are nonspecific and their classification is based not only on substrate specificity but also on tissue distribution, inhibition properties and physicochemical characteristics such as electrophoretic mobility and molecular weight. In contrast to PON1, which is expressed mainly in the liver, PON2 is expressed in a variety of mouse tissues, including the pancreas. PON3 is a associated with the high density lipoprotein fraction of serum. The genes which encode PON1-3 are physically linked and map to human chromosome 7q21.3.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human PON1 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for PON1

Target: PON1 (Paraoxonase 1 (PON1))

Alternative Name: PON1

Background:

A-esterase 1, Aromatic esterase 1, Arylesterase 1, Arylesterase B type, ESA, Esterase A, K 45, MVCD5, Paraoxonase 1, Paraoxonase B type, Paraoxonase, plasma, Serum aryldialkylphosphatase 1, Serum paraoxonase/arylesterase 1

Human liver.

Molecular Weight: 43kDa

Gene ID: 5444, 370995

UniProt: P27169