Recombinant HLA-ABC antibody (AA 100-300)

Catalog No. ABIN7864329

The Rabbit Monoclonal anti-HLA-ABC antibody is suitable to detect HLA-ABC in samples from Human and Guinea Pig. It has been validated for WB and IHC.

Quick Overview for Recombinant HLA-ABC antibody (AA 100-300) (ABIN7864329)

Target: HLA-ABC

Antibody Type: Recombinant Antibody

Reactivity: Human, Guinea Pig

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HLA-ABC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: MHC-I-8366R

Product Details anti-HLA-ABC Antibody

Binding Specificity: AA 100-300

Purpose: Recombinant HLA Class 1 ABC (MHC I) Antibody

Specificity: Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class 79oΩ 79oΩ, class 79oΩ 79oΩ and class 79oΩ 79oΩ gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex 79oΩ 79oΩ (MHC 79oΩ 79oΩ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC 79oΩ 79oΩ is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC 79oΩ 79oΩmolecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa100-300) of human HLA-I protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for HLA-ABC

Target: HLA-ABC

Alternative Name: HLA Class 1 ABC

Background:

Antigen Presenting Molecule, Cw*1701, D6S204, FLJ27082, HLA A, HLA B, HLA C, HLA class 1 A, HLA class 1 B, HLA class 1 C, HLA JY3, HLAA, HLAB, HLAC, HLC C, Human Leucocyte Antigen C, Major Histocompatibility Complex Class I A, Major Histocompatibility Complex Class I B, Major Histocompatibility Complex Class I C,

HOP-92, Tonsil, Raji, Hep G2 or lymph node. Human Lung, Human Liver or THP-1

Molecular Weight: 40/41kDa

Gene ID: 3105, 3106, 3107

UniProt: P01889, P30443, P30499

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints