Mannose Receptor antibody (AA 1100-1400)

Catalog No. ABIN7865253

The Mouse Monoclonal anti-Mannose Receptor antibody is suitable to detect Mannose Receptor in samples from Human. It has been validated for IHC.

Quick Overview for Mannose Receptor antibody (AA 1100-1400) (ABIN7865253)

Target: Mannose Receptor (MR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mannose Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: MRC1-9454

Product Details anti-Mannose Receptor Antibody

Binding Specificity: AA 1100-1400

Purpose: Mannose Receptor / CD206 Antibody

Specificity: CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1100-1400) of human MRC1 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Mannose Receptor

Target: Mannose Receptor (MR)

Alternative Name: Mannose Receptor

Background: C-type lectin domain family 13 member D, human mannose receptor, macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1

Molecular Weight: 160-170kDa

Gene ID: 4360, 75182

UniProt: P22897