Paired Box 3 antibody (AA 150-350)

Catalog No. ABIN7859229

The Mouse Monoclonal anti-Paired Box 3 antibody is suitable to detect Paired Box 3 in samples from Human. It has been validated for IHC.

Quick Overview for Paired Box 3 antibody (AA 150-350) (ABIN7859229)

Target: Paired Box 3 (PAX3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Paired Box 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PAX3-8424

Product Details anti-Paired Box 3 Antibody

Binding Specificity: AA 150-350

Purpose: PAX3 Antibody

Specificity: Pax genes contain paired domains that share strong homology to genes in Drosophila which are involved in programming early development. The product of the PAX3 gene is a DNA-binding protein expressed during early neurogenesis. Pax-3 is a protein containing both a paired domain and a paired-type homeodomain. During early neurogenesis, Pax-3 expression is limited to mitotic cells in the ventricular zone of the developing spinal cord and to distinct regions in the hindbrain, midbrain and diencephalon. In 10-12 day embryos, expression of Pax-3 is also seen in neural crest cells of the developing spinal ganglia, the craniofacial mesectoderm and in limb mesenchyme. Mutations in the MITF and Pax-3 genes, encoding transcription factors, are responsible for Waardenburg syndrome II (WSII) and WSI/WSIII, respectively.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa150-350) of human PAX3 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Paired Box 3

Target: Paired Box 3 (PAX3)

Alternative Name: PAX3

Background:

CDHS, HUP2, Paired box 3, Paired box homeotic gene 3, Paired box protein Pax 3, Paired domain gene HuP2, PAX3/FKHR fusion gene, Sp, splotch, Waardenburg syndrome 1, WS1, WS3

Human skin and skeletal muscle tissue.

Molecular Weight: 56kDa

Gene ID: 5077, 42146

UniProt: P23760

Pathways: Sensory Perception of Sound, Tube Formation