Aquaporin 4 antibody (AA 200-323)

Catalog No. ABIN7865396

The Mouse Monoclonal anti-Aquaporin 4 antibody is suitable to detect Aquaporin 4 in samples from Human. It has been validated for IHC.

Quick Overview for Aquaporin 4 antibody (AA 200-323) (ABIN7865396)

Target: Aquaporin 4 (AQP4)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Aquaporin 4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AQP4-3322

Product Details anti-Aquaporin 4 Antibody

Binding Specificity: AA 200-323

Purpose: Aquaporin 4 (AQP4) Antibody

Specificity: In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. AQP2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Human recombinant AQP4 protein fragment (around aa200-323) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Aquaporin 4

Target: Aquaporin 4 (AQP4)

Alternative Name: Aquaporin 4

Background:

WCH4, Mercurial-insensitive water channel (MIWC), HMIWC2

Human skeletal muscle, small intestine or brain tissue.

Molecular Weight: 34kDa

Gene ID: 361, 315369

UniProt: P55087

Pathways: Sensory Perception of Sound