DBH antibody (AA 200-400)

Catalog No. ABIN7864919

The Mouse Monoclonal anti-DBH antibody (Clone DBH-7222) (ABIN7864919) specifically detects DBH in IHC. The antibody is reactive with Human samples.

Quick Overview for DBH antibody (AA 200-400) (ABIN7864919)

Target: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DBH antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DBH-7222

Product Details anti-DBH Antibody

Binding Specificity: AA 200-400

Purpose: DBH / Dopamine Beta-Hydroxylase Antibody

Specificity: Dopamine ≤-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-400) of human DBH protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for DBH

Target: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Alternative Name: DBH

Background:

dbh, DBM, Dopamine beta hydroxylase, Dopamine beta monooxygenase, Dopamine beta-hydroxylase (dopamine beta-monooxygenase), Soluble dopamine beta-hydroxylase

Human adrenal gland or adrenal pheochromocytoma.

Molecular Weight: 78/84 kDa

Gene ID: 1621, 591890

UniProt: P09172

Pathways: Carbohydrate Homeostasis