LAMP1 antibody (AA 200-400)

Catalog No. ABIN7864828

The Mouse Monoclonal anti-LAMP1 antibody (Clone LAMP1-7458) (ABIN7864828) specifically detects LAMP1 in IHC. The antibody is reactive with Human samples.

Quick Overview for LAMP1 antibody (AA 200-400) (ABIN7864828)

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAMP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: LAMP1-7458

Product Details anti-LAMP1 Antibody

Binding Specificity: AA 200-400

Purpose: CD107a / Lysosomal associated membrane protein 1 (LAMP1) Antibody

Specificity: Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrincoated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-400) of human LAMP1 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for LAMP1

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Alternative Name: CD107a

Background:

CD107 antigen like family member A, LAMP1, LAMPA, LGP120, lgpA, Lysosomal membrane glycoprotein 120KD, Lysosomal Associated Membrane Protein 1, Lysosome associated membrane glycoprotein 1, OTTHUMP00000040663

Human tonsil|kidney or prostate.|Placenta

Molecular Weight: 120 kDa

Gene ID: 3916, 494419

Pathways: Autophagy