Recombinant PAPPA antibody (AA 351-523)

Catalog No. ABIN7860004

The Rabbit Monoclonal anti-PAPPA antibody (Clone PAPPA-8804R) (ABIN7860004) specifically detects PAPPA in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant PAPPA antibody (AA 351-523) (ABIN7860004)

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PAPPA antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PAPPA-8804R

Product Details anti-PAPPA Antibody

Binding Specificity: AA 351-523

Purpose: Recombinant PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Antibody

Specificity: Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for PAPPA

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Alternative Name: PAPP-A

Background:

ASBABP2, Aspecific BCL2 ARE binding protein 2, Differentially placenta 1 expressed protein, DIPLA1, IGF-dependent, IGFBP4ase, Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGFBP-4 protease), PAPA, PAPP A, PAPPA1, Pappalysin-1, Pregnancy Associated Plasma Protein A (PAPP-A)

Human placenta tissue.

Molecular Weight: 181kDa

Gene ID: 5069, 643599

UniProt: Q13219