MMP2 antibody (AA 557-569)

Catalog No. ABIN7860396

The Mouse Monoclonal anti-MMP2 antibody is suitable to detect MMP2 in samples from Human. It has been validated for IHC.

Quick Overview for MMP2 antibody (AA 557-569) (ABIN7860396)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: 4D3

Product Details anti-MMP2 Antibody

Binding Specificity: AA 557-569

Purpose: MMP2 / Collagenase Type IV A (Tumor Metastasis Marker) Antibody

Specificity: It recognizes a protein of 72 kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV,V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human MMP2 protein fragment (aa557-569)

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2

Background:

72kD type IV collagenase, CLG4A, Collagenase Type 4 alpha, Collagenase type IV A, Gelatinase A, Gelatinase alpha, Gelatinase neutrophil, Matrix metalloproteinase-2, MMP2, MONA, Neutrophil gelatinase, PEX, TBE-1

U-138 MG or U-87 MG cells. Human placenta or colon carcinoma.

Molecular Weight: 72kDa (Pro), 63kDa (cleaved)

Gene ID: 4313, 513617

UniProt: P08253

Pathways: Activation of Innate immune Response